With the quarter-season mark now being reached, Saints will be looking to kick off our next batch of fixtures with a first away win of the campaign.
That will be no mean feat, though, given West Brom have started the campaign well under newly-appointed head coach Steve Clarke, who stepped into the vacancy left by Roy Hodgson this summer.
The Baggies went into this weekend's round of fixtures sitting eight in the Barclays Premier League standings – though they could well have been even higher in the table.
Clarke's side have lost their last two games – against Manchester City then Newcastle – thanks to injury-time goals, with a win in either of those fixtures enough to have put Albion into the top five.
Saints' First Team Manager Nigel Adkins revealed in his pre-match press conference that Gastón Ramírez and Jack Cork are back in full training and could be involved at the Hawthorns on Monday.
Ramírez has been missing for the past month with a thigh issue, while Cork has yet to make Premier League appearance this season due to ankle and knee problems.
Adkins is likely to make wholesale changes to the side which started Saints' Capital One Cup loss at Leeds last Tuesday, when he rested 11 first-team players.
Tadanari Lee returned from an arm injury in that game and will hope to make his first top-flight appearance tomorrow, though defender Frazer Richardson remains out with a thigh injury.
For the hosts, Shane Long and Claudio Yacob are rated by boss Clarke as having a 50-50 chance of being involved in Monday's game.
Defender Billy Jones has been declared fit after recovering from a knee injury, as has Chris Brunt following a hamstring issue.
Steven Reid, though, will not be fit to return to the team despite resuming training after a hamstring problem of his own.
My prediction: West Brom 2-1 Saints.