City boss Roberto Mancini will make a late call on whether Carlos Tevez will be involved as he battles to prove his fitness ahead of the FA Cup final.
They are boosted by the return of Gareth Barry and Micah Richards from hamstring injuries.
Tottenham's Gareth Bale ruptured ankle ligaments against Blackpool and has been ruled out for the season.
They are also sweating on the fitness of playmaker Luka Modric and striker Peter Crouch.
Manchester City
Doubtful: Tevez (hamstring), Zabaleta (unspecified)
Injured/unavailable: Boateng & M Johnson (both knee), Given (shoulder), K Toure (club suspension)
Tottenham
Doubtful: Crouch (back), Modric (hip)
Injured: Assou-Ekotto (hamstring), Bale & Huddlestone (both ankle), Hutton & Palacios (both knee), Khumalo (foot), King (groin), Woodgate (calf)
Must win for both. City win, they are in the Champions league. Spurs win, it edges them closer to top 4.